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SCIENTISTS SHOWS THAT CHICKEN COULD CURE DEAFNESS

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Offline Timi Dapsin

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SCIENTISTS SHOWS THAT CHICKEN COULD CURE DEAFNESS
« on: May 22, 2014, 08:27:21 PM »




The ability to recognize pitch and to listen to the distinction between similar-sounding words depends on specialised cells inside the sensory receptor, which might be broken.

For the first time, scientists have discovered what controls the cells’ development and pattering.

They studied the event of those cells in chickens, that in contrast to humans, have the capability to produce sound-detecting cells when suffering deafness.
Scientists have discovered what controls the event and pattering of cells within the sensory receptor. They studies their development in chickens, which might regenerate broken cells. A colored mcg of the hair cells that discover pitch ar pictured, with stereocilia (hair-like microscopic protrusions) in blue
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Scientists have discovered what controls the event and pattering of cells within the sensory receptor. They studies their development in chickens, which might regenerate broken cells. A colored mcg of the hair cells that discover pitch ar pictured, with stereocilia (hair-like microscopic protrusions) in blue



HOW WILL WE HEAR PITCH?

Pitch detection happens inside the tube, that may be a little spiral structure inside the sensory receptor.

Inside the tube ar specialised cells, referred to as hair cells, that ar tuned to completely different sound pitches primarily based partially, on their locations on the cochlea’s spiral and also the variety and also the length of their stereocilia, that ar hair-like microscopic protrusions that offer the cells their name.

High-pitched sounds ar detected by cells with shorter hair bundles, set nighest to wherever sound enters the ear, whereas lower-pitched sounds ar detected by cells with taller hair bundles set additional in. This pattern progresses through the many thousand hair cells that ar essential for hearing.

Not each single epithelial cell within the tube responds to sounds – solely those that ar sensitive to specific frequencies respond.

A study by the University of Virginia college of drugs and also the National Institute on hearing impairment and Communication Disorders says that if scientists perceive what causes chickens’ cells to redevelop they may at some point replicate the method in humans to reverse deafness.

Jeffrey Corwin of the university same that if each an individual's and a hen were to be exposed to a sound loud enough to destroy the flexibility to listen to an exact pitch, the outcomes would be terribly completely different.

‘We would lose the flexibility to listen to that sound for the remainder of our lives.

'The bird conjointly would lose the flexibility, however inside ten days, it'd have its cells back – they'd hook keep a copy to the nerves and inside a couple of weeks its hearing would be back and nearly indistinguishable from before.’

‘Eventually therapies [for humans] can ensue from this regenerative approach and these new discoveries are going to be a vital element,’ he said.

Pitch detection happens inside the tube, that may be a little spiral structure inside the sensory receptor.

Inside the tube ar specialised cells, referred to as hair cells, that ar tuned to completely different sound pitches primarily based partially on their locations on the cochlea’s spiral and also the variety and also the length of their stereocilia, that ar hair-like microscopic protrusions that offer the cells their name.
Egg-straordinary! consultants believe that if they'll perceive what causes chickens' cells to redevelop, they may replicate the method in humans, that may probably reverse deafness at some point
+2

Egg-straordinary! consultants believe that if they'll perceive what causes chickens' cells to redevelop, they may replicate the method in humans, that may probably reverse deafness at some point

High-pitched sounds ar detected by cells with shorter hair bundles, set nighest to wherever sound enters the ear, whereas lower-pitched sounds ar detected by cells with taller hair bundles set additional in. This pattern progresses through the many thousand hair cells that ar essential for hearing.

Benjamin Thiede, lead author of the 2 papers, that ar printed in Nature Communications, explained: ‘When you hear completely different sounds, not each single epithelial cell within the tube is responding - solely those that ar sensitive to the precise sound frequencies.’

Until now, scientists haven't understood what orchestrates the formation of this pattern of one by one distinct hair cells. however currently they need resolved that mystery, demonstrating that 2 specific molecules - Bmp7 and retinoic acid - guide cells to accumulate location-specific attributes.

Bmp7 starts the initial patterning method and retinoic acid regulates however the cells’ hair bundles grow to completely different lengths.

Dr Thiede found proof that there ar completely different levels of retinoic acid activity on the length of the tube, therefore he tried adding additional retinoic acid in cells fully grown in a very research lab dish and located that they created longer hair bundles.

Then he used a drug to dam retinoic acid’s activity and located that resulted in shorter bundles.

He noted that once chickens regenerate broken hair cells, the new cells develop with simply the proper characteristics for cells in those specific locations on the tube.

‘So the question is, ar biological process signals like Bmp7 and retinoic acid concerned in re-establishing the pattern of hair cells and restoring hearing to the create cochlea?’ he asked.

He believes the creation of signals for reactivating regeneration of the molecules may be a ‘tantalising’ path for developing new treatments for deafness.


« Last Edit: May 25, 2014, 08:20:09 PM by Timi Dapsin »



 


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